The search yielded 15 studies that related the use of KD in mental disorders including anxiety, depression, bipolar disorder, schizophrenia, autism spectrum disorder (ASD), and attention deficit hyperactivity disorder (ADHD). These studies comprised nine animal models, four case studies, and two open-label studies in humans. In anxiety, exogenous ketone supplementation reduced anxiety-related behaviors in a rat model. In depression, KD significantly reduced depression-like behaviors in rat and mice models in two controlled studies. In bipolar disorder, one case study reported a reduction in symptomatology, while a second case study reported no improvement. In schizophrenia, an open-label study in female patients (n = 10) reported reduced symptoms after 2 weeks of KD, a single case study reported no improvement. In a brief report, 3 weeks of KD in a mouse model normalized pathological behaviors. In ASD, an open-label study in children (n = 30) reported no significant improvement; one case study reported a pronounced and sustained response to KD. In ASD, in four controlled animal studies, KD significantly reduced ASD-related behaviors in mice and rats. In ADHD, in one controlled trial of KD in dogs with comorbid epilepsy, both conditions significantly improved.

Conclusion

Despite its long history in neurology, the role of KD in mental disorders is unclear. Half of the published studies are based on animal models of mental disorders with limited generalizability to the analog conditions in humans. The review lists some major limitations including the lack of measuring ketone levels in four studies and the issue of compliance to the rigid diet in humans. Currently, there is insufficient evidence for the use of KD in mental disorders, and it is not a recommended treatment option. Future research should include long-term, prospective, randomized, placebo-controlled crossover dietary trials to examine the effect of KD in various mental disorders.

동물실험 결과는 ADHD, 자폐, 조울증, 정신분열 등등 다 좋게 나옴 그런데 동물 정신질환을 인간에게 적용하는데 있어서 한정된 일반화를 기반으로 했다고 하고 사람대상으로 한 실험들은 엄격한 식사를 제한할수없고 케톤레벨을 정확하게 측정하기 힘들어서 증거 불충분 이라고 하네

미국 의료학계 주류이론은 LCHF는 체네 콜레스테롤 늘린다고 위험하다고 하는중

콜레스테롤 섭취랑 체네 콜레스테롤이랑 관계없다는게 얼마전에 반영되서 콜레스테롤은 섭취영양소 기준에서 뺏음.....

이거때문에 학계내에서도 치고박고싸우는 중임ㅋㅋㅋㅋ

우리나라에서도 얼마전까지 붐이였던거 같은데 난 이제 알았네 ㅋㅋㅋㅋㅋㅋ

의사마다 의견도 다르고 연구결과도 많이 없어서 핫토픽인듯 근데 실제 다이어트 효과본사람은 많이있는거같네

사실 제일 안전한건 학계 주류이론이긴한데 포화지방 섭취가 늘게되면 LDL수치가 증가하는건 팩트

근데 이 수치가 관련없다는 연구도 있기는해

뇌의 연료를 탄수화물말고 케톤으로 돌리는게 ADHD 도움될수도 있다는 생각이 듬 갠적으로 실험해볼생각임