(서울=연합뉴스) 이해영 기자 = 

톡소플라스마(Toxoplasma ) 기생충에 감염된 사람은 창업 지향성이 강하다는 연구결과가 나왔다. 

미국 콜로라도 대학 학자 등으로 구성된 연구팀은 25일자 영국 왕립협회 학술지에 이런 연구결과를 발표했다고 교도(共同)통신이 전했다. 

인과관계는 증명할 수 없지만 호르몬이나 뇌의 정보전달물질 상태를 바꿔 감염자가 리스크가 높은 행동을 하도록 부추길 가능성도 있다고 한다.

연구팀은 먼저 미국 대학생 1천500명을 대상으로 톡소플라스마 감염 여부를 조사했다. 타액검사에서 감염판정을 받은 학생은 감염되지 않은 학생에 비해 비즈니스계통의 전공을 선택하는 비율이 1.4배 높았다. 전공 중에서도 회계나 재무보다는 경영이나 창업관련 공부를 하는 비율이 1.7배였다. 사회인 200여명을 대상으로 한 조사에서도 감염자의 창업경험 비율이 비감염자의 1.8배로 나타났다.

42개국의 조사통계를 분석한 결과에서도 감염률이 높은 국가일수록 창업에 적극적인 경향이 있는 것으로 분석됐다.

톡소플라스마는 사람의 경우 덜 익힌 고기나 고양이의 배설물 등을 통해 감염되는 인수공통 기생성 원충(原蟲)으로 세계적으로 20억명 정도가 감염된 것으로 추정되고 있다. 그동안의 연구에서는 톡소플라스마에 감염된 쥐가 고양이의 배설물을 싫어하지 않게 되거나 감염된 사람은 교통사고와 자살, 과도한 음주 사례가 많다는 연구결과가 보고됐다

물론 이것만이 원인은 아니겠지만 위의 인과관계를 증명하면 

ADHD, 파킨슨,자폐,조현병,안구운동장애,기분장애등 을 풀어내는 퍼즐조각을 얻게됨.

삼성에서 올해 6월에 AI개발목적으로 영입한 세바스찬 승이란 사람이 있음.

이사람은 '커넥텀'이란 개념으로 대뇌피질의 신경망을 연구한다 함. 

이런사람들이 막 숍숍 해내서 감추지 않고 공개했으면 좋겠다.

내 망상으로는 무언가를 실행하는 더블클릭은 기저핵이랑 그 주변놈들이 할 듯.

기사2

Toxoplasma gondii, a parasitic protozoan, infects about 30–60% of people worldwide. The latent toxoplasmosis, i.e. life-long presence of cysts in the brain and muscular tissues, has no effect on human health. However, infected subjects score worse in psychomotor performance tests and have different personality profiles than Toxoplasma-negative subjects. The mechanism of this effect is unknown; however, it is supposed that presence of parasites’ cysts in the brain induces an increase of the concentration of dopamine. Here we search for the existence of differences in personality profile between Toxoplasma-positive and Toxoplasma-negative subjects by testing 857 military conscripts using a modern psychobiological questionnaire, namely with Cloninger's Temperament and Character Inventory (TCI). ANCOVA showed that Toxoplasma-positive subjects had lower Novelty seeking (NS) scores (P=0.035) and lower scores for three of its four subscales, namely Impulsiveness (P=0.049), Extravagance (P=0.056) and Disorderliness (P=0.006) than the Toxoplasma-negative subjects. Differences between Toxoplasma-negative and positive subjects in NS was inversely correlated with duration of toxoplasmosis estimated on the basis of concentration anti-Toxoplasma antibodies (P=0.031). Unexpectedly, the infected subjects had also lower IQ (P2=0.003) and lower probability of achieving a higher education (P2

The Distribution of Toxoplasma gondii Cysts in the Brain of a Mouse with Latent Toxoplasmosis: Implications for the Behavioral Manipulation Hypothesis

Background

The highly prevalent parasite Toxoplasma gondii reportedly manipulates rodent behavior to enhance the likelihood of transmission to its definitive cat host. The proximate mechanisms underlying this adaptive manipulation remain largely unclear, though a growing body of evidence suggests that the parasite-entrained dysregulation of dopamine metabolism plays a central role. Paradoxically, the distribution of the parasite in the brain has received only scant attention.

Methodology/Principal Findings

The distributions of T. gondii cysts and histopathological lesions in the brains of CD1 mice with latent toxoplasmosis were analyzed using standard histological techniques. Mice were infected per orally with 10 tissue cysts of the avirulent HIF strain of T. gondii at six months of age and examined 18 weeks later. The cysts were distributed throughout the brain and selective tropism of the parasite toward a particular functional system was not observed.

Importantly, the cysts were not preferentially associated with the dopaminergic system and absent from the hypothalamic defensive system. The striking interindividual differences in the total parasite load and cyst distribution indicate a probabilistic nature of brain infestation.

Still, some brain regions were consistently more infected than others. These included the olfactory bulb, the entorhinal, somatosensory, motor and orbital, frontal association and visual cortices, and, importantly, the hippocampus and the amygdala.

By contrast, a consistently low incidence of tissue cysts was recorded in the cerebellum, the pontine nuclei, the caudate putamen and virtually all compact masses of myelinated axons. Numerous perivascular and leptomeningeal infiltrations of inflammatory cells were observed, but they were not associated with intracellular cysts.

Conclusion/Significance

The observed pattern of T. gondii distribution stems from uneven brain colonization during acute infection and explains numerous behavioral abnormalities observed in the chronically infected rodents. Thus, the parasite can effectively change behavioral phenotype of infected hosts despite the absence of well targeted tropism.

https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0028925

자료3번

MicroRNA-132 dysregulation in Toxoplasma gondii infection has implications for dopamine signaling pathway

30 May 2014

https://www.sciencedirect.com/science/article/abs/pii/S0306452214002218